Satellite Meeting 3 (Blenheim Suite)
Microfocus Macromolecular Crystallography:
What to do when small is not only beautiful but all you can get
Organised by Dr. Liz Duke, Diamond
The ability to obtain only small crystals of biological systems is becoming an increasingly common problem in all areas of macromolecular crystallography as scientists work on more and more challenging systems. Additionally it is frustratingly easy to grow large crystals in one dimension but the other two dimensions are less than 20mm in size (needles and plates). Collecting data on these types of crystals is exceedingly difficult, demanding much patience from the experimenter. Synchrotron beamlines with instrumentation dedicated to making the challenges surmountable have gone a long way to ensuring that some spectacular results have been achieved.
The satellite meeting program will focus on both the beamlines and instrumentation already available for microfocus MX work and the developments that are currently taking place. In addition some of the results already obtained will be presented. Finally, to ensure participants don’t leave with rose coloured spectacles, the problems which are encountered in the field will also be discussed.
Tuesday 13th (afternoon)
- 15:00Break out from Main User Meeting
- 15:10 Dr. Liz Duke (Diamond Light Source)
- Welcome
- Session 1 Chair - Dr. Thomas Sorensen (Diamond Light Source)
- Microcrystals: Scientific Achievements and Work in Progress
- 15:15 Prof. Dave Stuart (University of Oxford)
- Studies on Microcrystals within Insect Cells
- 16:00 Dr. Gebhard Schertler (LMB, Cambridge)
- Structural Studies on microcrystals of rhodopsin
- 16:45 Dr. Dina Fotinou (SGC Oxford)
- Interactions of tetanus toxin hc and carbohydrates
- 17:15 Dr. Steve Gamblin (NIMR Mill Hill)
- Insights into the mechanism of the retinoblastoma tumour suppressor protein from microdiffractometer data
- 17:45 Session 1
- Close
Wednesday 14th (morning)
- Session 2 Chair - Dr. Liz Duke (Diamond Light Source)
- Microfocus: Delivering the radiation and all the problems that can bring
- 09:00 Dr. David Flot (MBL Grenoble)
- ID23-2: a ESRF beam line for very small protein crystals
- 09:30 Dr. Gwyndaf Evans (Diamond Light Source)
- A microfocus beamline for MX at Diamond
- 10:00 Dr. Miroslav Papiz (SRS Daresbury Laboratory)
- A facility for screening and improving the diffraction quality of small crystals
- 10:30 Dr. John Cowan (SRS Daresbury Laboratory)
- Radiation Damage and Microfocus Macromolecular Crystallography
- 11:00 Coffee break
- Rejoin SR Users Meeting
