1. X. Zhang, S.M. Roe, L.H. Pearl and C.J. Danpure. (2001)
   Crystallisation and preliminary crystallographic analysis of human alanine: glyoxylate aminotransferase and its polymorphic variants.
   Acta Cryst., D57, 1936-1937 (9.6)

2. C.W. Levy, P.A. Buckley, P.J. Baker, S. Sedelnikova, F. Rogers, Y.F. Li, Y. Kato, Y. Asano and D.W. Rice. (2001).
   Crystallisation and preliminary X-ray analysis of Citrobacter amalonaticus methylaspartate ammonia lyase.
   Acta Cryst., D57, 1922-1924 (9.6)

3. J.A. Harrison, A.W. Schüttelkopf, D.H. Boxer and W.N. Hunter (2001).
   Crystallisation and X-ray diffraction measurements on recombinant molbindin, MopII, from Clostridium pasteurianum.
   Acta Cryst., D57, 1715-1717 (9.6)

4. S.S. Sturrock, D.T.F. Dryden, C. Atanasiu, J. Dornan, S. Bruce, A. Cronshaw, P. Taylor and M.D. Walkinshaw (2001).
   Crystallisation and preliminary X-ray analysis of ocr, the product of gene 0.3 of bacteriophage T7.
   Acta Cryst., D57, 1652-1654 (9.5)

5. A.R. Dalby, D.R. Tolan and J.A. Littlechild (2001).
   The structure of human liver fructose-1,6-bisphosphate adolase.
   Acta Cryst., D57, 1526-1533 (9.6)

6. S. K. Das, S. E. Sedelnikova, P. J. Baker, S. N. Ruzheinikov, S. Foster, A. Hartley, M.J. Horsburgh and D. W. Rice (2001).
   Cloning, purification, crystallization and preliminary crystallographic analysis of Bacillus subtilis LuxS
   Acta Cryst., D57, 1324-1325 (9.6)

7. I. D. Kerr, R. I. M. Wadsworth, W. Blankenfeldt, A. G. Staines, M. F. White and J. H. Naismith (2001).
   Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus
   Acta Cryst., D57, 1290-1292 (9.6)

8. M. Cianci, P. J. Rizkallah, A. Olczak, J. Raftery, N. E. Chayen, P. F. Zagalsky and J.R. Helliwell (2001).
   Structure of lobster apocrustacyanin A1 using softer X-rays
   Acta Cryst., D57, 1219-1229 (7.2/9.5/9.6)

9. K. L. Britton, I. S. B. Abeysinghe, P. J. Baker, V. Barynin, P. Diehl, S. J. Langridge, B.A. McFadden, S. E. Sedelnikova, T. J. Stillman, K. Weeradechapon and D. W. Rice (2001).
   The structure and domain organization of Escherichia coli isocitrate lyase
   Acta Cryst., D57, 1209-1218 (9.5)

10. T.A. Muranova, S.N. Ruzheinikov, S.E. Sedelnikova, A. Moir, L.J. Partridge, H. Kakinuma, K. Shimazaki, J. Sun, Y. Nishi and D.W. Rice. (2001).
    The preparation and crystallisation of FAB fragments of a family of mouse esterolytic catalytic antibodies and their complexes with a transition-state analogue.
    Acta Cryst., D57, 1192-1195. (9.6/14.1)

11. A. Roujeinikova, C. Raasch, S. Sedelnikova, W. Liebl and D.W. Rice. (2001).
    Crystallisation and preliminary X-ray crystallographic studies on 4-glucanotransferase from Thermotoga maritima.
    Acta Cryst., D57, 1046-1047. (14.2)

12. S.E. Sedelnikova, S.H.J. Smits, P.M. Leonard, A.B. Brinkman, J. van der Oost, J.B. Rafferty and D.W. Rice. (2001).
    Crystallisation and quaternary structure analysis of an Lrp-like regulatory protein from the hyperthermophile Pyrococcus furiosus.
    Acta Cryst., D57, 886-888. (7.2)

13. R. Persson, M. Harkiolaki, J. McGeehan and K.S. Wilson. (2001).
    Crystallisation and preliminary crystallographic analysis of deoxyuridine 5'-triphosphate nucleotidohydrolase from Bacillius subtilis.
    Acta Cryst., D57, 876-878. (14.1)

14. C.E. Naylor, S. Gover, A.K. Basak, M.S. Cosgrove, H.R. Levy and M.J. Adams. (2001).
    NADP⁺ and NAD⁺ binding to the dual coenzyme specific enzyme Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: different interdomain hinge angles are seen in different binary and ternary complexes.
    Acta Cryst., D57, 635-648. (9.5/9.6)

15. S.J. Davis, S. Ikemizu, A.V. Collins, J.A. Fennelly, K. Harlos, E.Y. Jones and D.I. Stuart. (2001).
    Crystallisation and functional analysis of a soluble deglycosylated form of the human costimulatory molecule B7-1.
    Acta Cryst., D57, 605-608. (14.2)

16. Teixeira, S., Lo Leggio, L., Pickersgill, R. and Cardin, C. (2001).
    Anisotropic refinement of the structure of Thermoascus aurantiacus xylanase I.
    Acta Cryst., D57, 385-392. (9.6)

17. P. R. Seavers, R. J. Lewis, J. A. Brannigan and A. J. Wilkinson. (2001).
    Crystallization and preliminary X-ray analysis of the sporulation factor SpoIIAA in its native and phosphorylated forms.
    Acta Cryst., D57, 292-295. (9.6/14.2)

18. K. H. G. Verschueren, C. Addy, E. J. Dodson and A. J. Wilkinson. (2001).
    Crystallization of full-length CysB of Klebsiella aerogenes, a LysR-type transcriptional regulator.
    Acta Cryst., D57, 260-262. (9.6)

19. D. Tisi, B. Bax and A. Loew. (2001).
    The three-dimensional structure of cytosolic bovine retinal creatine kinase.
    Acta Cryst., D57, 187-193. (9.5)

20. Burke, J., Ruzheinikov, S., Sedelnikova, S., Baker, P., Holmes, D., Muir, N., Gore, M. & Rice, D. (2001).
    Purification, crystallisation and quaternary structure analysis of a glycerol dehydrogenase S305C mutant from Bacillus stearothermophilus.
    Acta Cryst. D57, 165-167. (14.2)

21. Lunin, V.Y., Lunina, N.L., Ritter, S., Frey, I., Berg, A., Diederichs, K., Podjarny, A.J., Urzhumtsev, A. & Baumstark, M.W. (2001).
    Low-resolution data analysis for low-density lipoprotein particle.
    Acta Cryst. D57, 108-121. (7.2)

1. Matak-Vincovic, D., Vinkovic, M., Saldanha, S.A., Ashurst, J.L., von Delft, F., Inoue, T., Miguel, R.N., Smith, A.G., Blundell, T.L. & Abell, C. (2001).
   Crystal structure of Escherichia coli ketopantoate reductase at 1.7 Å resolution and insight into the enzyme mechanism.
   Biochemistry, 40, 14493-14500. (9.6)

2. Ost, T.W.B., Munro, A.W., Mowat, C.G., Taylor, P.R., Pesseguiero, A., Fulco, A.J., Cho, A.K., Cheesman, M.A., Walkinshaw, M.D. & Chapman, S.K. (2001).
   Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3.
   Biochemistry, 40, 13430-13438. (9.5)

3. Murray, J.M., Kurtis, C.R., Tambyrajah, W., Saysell, T.G., Wilmot, C.M., Parsons, M.R., Phillips, S.E.V., Knowles, P.F. & McPherson, M.J. (2001).
   Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential.
   Biochemistry, 40, 12808-12818. (9.5)

4. McLuskey, K., Prince, S.M., Codgell, R.J. & Isaacs, N.W. (2001).
   The crystallographic structure of the B800-820 LH3 light-harvesting complex from the purple bacteria rhodopseudomonas acidophila strain 7050.
   Biochemistry, 40, 8783-8789. (9.6)

5. Edwards, S.D. & Keep, N.H. (2001).
   The 2.7 Å crystal structure of the activated FERM domain of Moesin: an analysis of structural changes on activation.
   Biochemistry, 40, 7061-7068. (9.5/9.6)

Insulin signalling pathways and a proposed mechanism for the ATP driven rotaion of the gamma subunit of F1-ATpase.

Menz, R.I., Walker, J.E. & Leslie, A.G.W. (2001) Structure of bovine mitochondrial F1-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism for rotary catalysis. Cell, 106, 331-342. (9.6). 1H8E Dajani, R., Fraser, E., Roe, S.M., Young, N., Good, V., Dale, T.C. & Pearl, L.H. (2001). Crystal structure of glycogen synthase kinase 3β: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell, 105, 721-732. (14.2). 1H8F

1. Clifton, I.J., Hsueh, L.C., Baldwin, J.E., Harlos, K. and Schofield, C.J. (2001).
   Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
   European Journal of Biochemistry, 268, 6625-6636. (7.2).

2. Poulas, K., Eliopoulos, E., Vatzaki, E., Navaza, J., Kontou, M., Oikonomakos, N., Acharya, K.R. and Tzartos, S.J. (2001).
   Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies.
   European Journal of Biochemistry, 268, 3685-3693. (7.2).

3. Wright, P.A., Wilmouth, R.C., Clifton, I.J. and Schofield, C.J. (2001).
   Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
   European Journal of Biochemistry, 268, 2969-2974. (9.6).

1. Ceschini, S., Keeley, A., McAlister, M.S.B., Oram, M., Phelan, J., Pearl, L.H., Tsaneva, I.R. & Barrett, T.E. (2001).
   Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.
   The EMBO Journal, 20, 6601-6611. (?)

2. Lietha. D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L. & Gherardi, E. (2001).
   Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
   The EMBO Journal, 20, 5543-5555. (14.1/14.2)

3. Yang, J., Dokurno, P., Tanks, N. & Barford, D. (2001).
   Crystal structure of the M-fragment of α-catenin: implications for modulation of cell adhesion.
   The EMBO Journal, 20, 3645-3656. (14.1)

4. Leonard, P.M., Smits, S.H.J., Sedelnikova, S.E., Brinkman, A.B., de Vos, W.M., van der Oost, J., Rice, D.W. & Rafferty, J.B. (2001).
   Crystal structure of the Lrp-like transcriptional regulator from the archeon Pyrococcus furiosus.
   The EMBO Journal, 20, 990-997. (7.2)

1. Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K., Fairweather, N. & Isaacs, N. (2001).
   The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
   Journal of Biological Chemistry, 276, 32274-32281. (7.2)

2. Lee, H.J., Lloyd, M.D., Harlos, K., Clifton, I.J., Baldwin, J.E. & Schofield, C.J. (2001).
   Alteration of the 2-oxoacid cosubstrate selectivity in deacetoxycephalosporin C Synthase: The role of arginine-258.
   Journal of Biological Chemistry, 276, 18290-18295. (9.6)

3. Leonidas, D.D., Boix, E., Prill, R., Suzuki, M., Turton, R., Minson, K., Swaminathan, G.J., Youle, R.J. & Acharya, K.R. (2001).
   Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN) - High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.
   Journal of Biological Chemistry, 276, 15009-15017. (9.5)

4. Iyer, S., Leonidas, D.D., Swaminathan, G.J., Maglione, D., Battisti, M., Tucci, M., Persico, M.G. & Acharya, K.R. (2001).
   The crystal structure of human placenta growth factor-1 (PlGF-1), a angiogenic protein, at 2.0 Å resolution.
   Journal of Biological Chemistry, 276, 12153-12161. (9.5)

5. Bond, C.S., White, M.F. & Hunter, W.N. (2001).
   High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase.
   Journal of Biological Chemistry, 276, 3247-3252. (9.6)

Petitpas, I., Grüne, T., Bhattacharya, A.A. & Curry, S. (2001). Crystal Structures of Human Serum Albumin Complexed with Monounsaturated and Polyunsaturated Fatty Acids Journal of Molecular Biology, 314, 955-960. (?) Chaillan-Huntington, C., Butler, P.J.G., Huntington, J.A., Akin, D., Feldherr, C. & Stewart, M. (2001). NTF2 Monomer-Dimer Equilibrium. Journal of Molecular Biology, 314, 465-477. (7.2) Ruzheinikov, S.N., Das, S.K., Sedelnikova, S.E., Hartley, A., Foster, S.J., Horsburgh, M.J., Cox, A.G., McCleod, C.W., Mekhalfia, A., Blackburn, G.M., Rice, D.W. & Baker, P.J. (2001). The 1.2 Å Structure of a Novel Quorum-sensing Protein, Bacillus subtilis LuxS. Journal of Molecular Biology, 313, 111-122. (9.6) Roujeinikova, A., Raasch, C., Burke, J., Baker, P.J., Liebl, W. & Rice, D.W. (2001). The Crystal Structure of Thermotoga maritima Maltosyltransferase and its Implications for the Molecular Basis of the Novel Transfer Specificity. Journal of Molecular Biology, 312, 119-131. (7.2/9.6) 1GJU Skordalakes, E., Dodson, G.G., St Clair Green, D., Goodwin, C.A., Scully, M.F., Hudson, H.R., Kakkar, V.V. & Deadman, J.J. (2001). Inhibition of Human α-Thrombin by a Phosphonate Tripeptide Proceeds via a Metastable Pentacoordinated Phosphorous Intermediate. Journal of Molecular Biology, 311, 549-555. (9.6) Read, J., Pearce, J., Li, X., Muirhead, H., Chirgwin, J. & Davies, C. (2001). The Crystal Structure of Human Phosphoglucose Isomerase at 1.6 Å Resolution: Implications for Catalytic Mechanism, Cytokine Activity and Haemolytic Anaemia. Journal of Molecular Biology, 309, 447-463. (7.2) Pederson, D.M., Welsh, L.C., Marvin, D.M., Sampson, M., Perham, R.N., Yu, M. & Slater, M.R. (2001). The Protein Capsid of Filamentous Bacteriophage PH75 from Thermus thermophilus. Journal of Molecular Biology, 309, 401-421. (7.2 - Fibre) Thom, R., Dixon, D.P., Edwards, R., Cole, D.J. & Lapthorn, A.J. (2001). The Structure of a Zeta Class Glutathione S-Transferase from Arabidopsis thaliana: Characterisation of a GST with Novel Active-site Architecture and a Putative Role in Tyrosine Catabolism. Journal of Molecular Biology, 308, 949-962. (7.2) Allard, S.T.M., Giraud, M.F., Whitfield, C., Graninger, M., Messner, P. & Naismith, J.H. (2001). The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar typhimurium, the second enzyme in the dTDP-L-rhammose pathway. Journal of Molecular Biology, 307, 283-295. (7.2) Ducros, V.M-A., Lewis, R.J., Verma, C.S., Dodson, E.J., Leonard, G., Turkenburg, J.P., Murshudov, G.N., Wilkinson, A.J. & Brannigan, J.A. (2001). Crystal Structure of GerE, the Ultimate Transcriptional Regulator of Spore Formation in Bacillus subtilis. Journal of Molecular Biology, 306, 759-771. (9.6) Stillman, T.J., Hempstead, P.D., Artymiuk, P.J., Andrews, S.C., Hudson, A.J., Treffry, A., Guest, J.R. & Harrison, P.M. (2001). The High-resolution X-ray Crystallographic Structure of the Ferritin (EcFtnA) of Escherichia coli; Comparison with Human H Ferritin (HuHF) and the Structures of the Fe(3+) and Zn(2+) Derivatives. Journal of Molecular Biology, 306, 587-603. (9.6) Szilagyi, A.N., Ghosh, M., Garman, E. & Vas, M. (2001). A 1.8 Å Resolution Structure of Pig Muscle 3-Phosphoglycerate Kinase with Bound MgADP and 3-Phosphoglycerate in Open Conformation: New Insight into the Role of the Nucleotide in Domain Closure. Journal of Molecular Biology, 306, 499-511. (7.2)

Anthrax Lethal Factor, an enzyme with high and unusual specificity. Arfaptin mediated signalling pathways, and evolutionary link between double stranded RNA viruses and flaviviruses.

Pannifer, A., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D.B., Collier, R.J., Park, S., Leppla, S.H., Hanna, P. & Liddington, R.C. (2001). Crystal structure of the anthrax lethal factor. Nature, Volume 414, 229-233. (9.6) 1J7N Tarricone, C., Xiao, B., Justin, N., Walker, P.A., Rittinger, K., Gamblin, S.J. & Smerdon, S.J. (2001). The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Nature, Volume 411, 215-218. (9.6) 1I49 Butcher, S.J., Grimes, J.M., Makeyev, E.V., Bamford, D.H. & Stuart, D.I. (2001). A mechanism for initiating RNA-dependent RNA polymerisation. Nature, Volume 410, 235-239. (9.6) 1HHS

The small heat shock protein and the balance between cell life and death. DDAH and the rational design of nitric oxide synthesise inhibitors. A fragment of mouse Nidogen basement membrane. Investigating molecular antifolate resistance with PTR1.

van Montfort, R.L.M., Basha, E., Friedrich, K.L., Slingsby, C. & Vierling, E. (2001). Crystal structure and assembly of a eukaryotic small heat shock protein. Nature Structural Biology, Volume 8, 1025-1030. (?) 1GME HSP16.9 Murray-Rust, J., Leiper, J., McAlister, M., Phelan, J., Tilley, S., Santa Maria, J., Vallance, P. & McDonald, N. (2001). Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase. Nature Structural Biology, Volume 8, 679-683. (9.5/14.1) 1H70 Gourley, D.G., Schüttelkopf, A.W., Leonard, G.A., Luba, J., Hardy, L.W., Beverley, S.M. & Hunter, W.N. (2001). Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasite. Nature Structural Biology, Volume 8, 521-525. (9.6) 1E7W, 1E92 Hopf, M., Göhring, W., Ries, A., Timpl, R. and Hohenester, E. (2001). Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1. Nature Structural Biology, Volume 8, 62-67. (9.6/14.1) Hadden, J.M., Convery, M.A., Declais, A-C., Lilley, D.M.J. and Phillips, S.E.V. (2001). Crystal structure of the Holliday junction resolving enzyme T7 endonuclease I. Nature Structural Biology, Volume 8, 634-640. (?) 1FZR

1. Greene, L.H., Chrysina, E.D., Irons, L.I., Papageorgiou, A.C., Acharya, K.R. & Brew, K. (2001).
   Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily.
   Protein Science, 10(11), 2301-2316. (9.5)

2. Leonidas, D.D., Chavali, G.B., Jardine, A.M., Li, S., Shapiro, R. & Acharya, K.R. (2001).
   Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.
   Protein Science, 10(8), 1669-1676. (9.5)

3. Izard, T. (2001).
   Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity.
   Protein Science, 10(8), 1508-1513. (9.6)

4. Krell, T., MacLean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J. & Coggins, J.R. (2001).
   Biochemical and X-ray crystallographic studies on shikimate kinase: The important structural role of the P-loop lysine.
   Protein Science, 10(6), 1137-1149. (9.6)

3OS Ribosomal subunit in complex with mRNA and tRNA.

Ford, M.G.J., Pearse, B.M.F.,Higgins, M.K., Vallis, Y., Owen, D.J., Gibson, A., Hopkins, C.R., Evans, P.R. & McMahon, H.T. (2001). Simultaneous binding of PtdIns(4,5)P-2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science, 291, 1051-1055. (9.6) Ogle, J.M., Brodersen, D.E., Clemons, W.M., Tarry, M.J., Carter, A.P. & Ramakrishnan, V. (2001). Recognition of Cognate Transfer RNA by the 3OS Ribosomal Subunit. Science, 292, 897-901. (14.1/14.2) 1IBK, 1IBL, 1IBM

Interactions between neurotrophins and TRK receptors. A high resolution structure of a xylanase module. Structural details of a novel family of polyol dehydrogenases. Catalase structural classes revealed. Comparison of phosphorylated and unphosphorilated SpollAA. New insights into recognition mechanism for TPR containing proteins and an aldolase with a unique active site.

Banfield, M.J., Naylor, R.L., Robertson, A.G., Allen, S.J., Dawbarn, D. & Brady, R.L. (2001). Specificity in Trk Receptor-Neurotrophin Interactions: The Crystal Structure of TrkB-d5 in Complex with Neurotrophin-4/5. . Structure with Folding and Design, 9, 1191-1200. (14.1) 1HCF Prates, J.A., Tarbouriech, N., Charnock, S.J., Fontes, C.M., Ferreira, L.M. & Davies, G.J. (2001). The Structure of the Feruloyl Esterase Module of Xylanase 10B from Clostridium thermocellum Provides Insights into Substrate Recognition. Structure with Folding and Design, 9, 1183-1190. (14.2) Ruzheinikov, S.N., Burke, J., Sedelnikova, S., Baker, P.J., Taylor, R., Bullough, P.A., Muir, N.M., Gore, M.G. & Rice, D.W. (2001). Glycerol Dehydrogenase: Structure, Specificity and Mechanism of a Family III Polyol Dehydrogenase. Structure with Folding and Design, 9, 789-802. (9.6/14.2) 1JPU, 1JQ5, 1JQA Barynin, V.V., Whittaker, M.M., Antonyuk, S.V., Lamzin, V.S., Harrison, P.M., Artymiuk, P.J. & Whittaker, J.W. (2001). Crystal Structure of Manganese Catalase from Lactobacillus plantarum. Structure with Folding and Design, 9, 725-738. (9.5/9.6) 1JKU, 1JKV Seavers, P.R., Lewis, R.J., Brannigan, J.A., Verschueren, H.G., Murshodov, G.N. & Wilkinson, A.J. (2001). Structure of the Bacillus Cell Fate Determinant SpoIIAA in Phosphorylated and Unphosphorylated Forms. Structure with Folding and Design, 9, 605-614. (14.1) 1HA2, 1H4X, 1H4Y, Taylor, P., Doman, J., Carrello, A., Minchin, R.F., Ratajczak, T. & Walkinshaw, M.D. (2001). Two Structures of Cyclophilin 40: Folding and Fidelity in the TPR Domains. Structure with Folding and Design, 9, 431-438. (9.6) Wymer, N., Buchanan, L.V., Henderson, D., Mehta, N., Botting, C.H., Pocivavsek, L., Fierke, C.A., Toone, E.J. & Naismith, J.H. (2001). Phosphogluconate Aldolase from Escherichia coli. Structure with Folding and Design, 9, 1-10. (9.6) 1FQ0, 1FWR