Draft Programme
Note: All talks will held in the Conference Auditoriumabstract=
Friday 6th
- 07:30-09:00Breakfast
- 08:30Registration
- Conference Auditorium
- 09.00-10:30Mini Workshop: What's New With CCP4
- Conference Auditorium
- 10:00Tea/Coffee
Session 1: Biology is Molecular Interactions 11:00-12:30
- 1Joël Janin (CNRS, Gif-sur-Yvette, France)
- Macromolecular recognition in the Protein Data Bank
- 2Michael Rossmann (Purdue University, US)
- From structure of the complex
to understanding of the biology
- 12:30Lunch
- Sports Hall
Session 2: Crystallography of Complexes Between Macromolecules (1) 14:00 - 15:30
- 3Kiyoshi Nagai (MRC, Cambridge)
- Preparation of large RNA-protein and protein
complexes for structure determination
- 4Tim Dafforn (University of Birmingham)
- How do we know we have a macromolecular complex?
- 5John Ladbury (University College, London)
- Measurement of the formation of protein
complexes in tyrosine kinase-mediated signal transduction
- 15:30Tea/Coffee
Session 3: Crystallography of Complexes Between Macromolecules (2) 16:00 - 18:00
- 6Airlie McCoy (Cambridge University, UK)
- Solving Difficult Molecular Replacement
Problems with Phaser
- 7Kim Henrick (EBI, Cambridge, UK)
- Protein Assemblies and the PDB
- 8Ruth Nussinov (National Cancer Institute, Frederick, US)
- Prediction of multi-molecular assemblies
at different resolutions
- 9Martin Noble (Oxford University, UK)
- Properties and complimentarity in complexes
- 18:00End of Session
- 19:00Conference Dinner
- The Refectory - menu
Saturday 7th
Session 4: Complexing proteins with small molecules 09:00 - 10:30
- 1Phil Evans (MRC, Cambridge, UK)
- Chemistry of small molecules for structural biologists
- 2Chun-wa Chung (GlaxoSmithKline, UK)
- Do we really have a complex? Detecting
ligand binding in solution
- 3Annie Hassell (GlaxoSmithKline, US)
- Crystallisation of protein-ligand
complexes (cocrystals, soaks, tricks)
- 10:30Coffee
Session 5: Molecular interactions in drug discovery 11:00 - 12:30
- 4Sandra Jacob (Novartis, Switzerland)
- Structural
biology contributions to the discovery of drugs to treat imatinib-resistant
chronic myelogenous leukaemia
- 5Thomas Lundquist (Astra Zeneca, Sweden)
- How to assess the drugability and full potential
of a drug target?
- 6David Brown (Pfizer, UK)
- Structure Based Drug Design
of Novel Inhibitors of cGMP Phosphodiesterase, PDE5.
Session 5: Crystallography of Protein-Small Molecule Complexes 14:00 - 16:00
- 7Gerard Kleywegt (Uppsala University, Sweden)
- Preventing cruelty against ligands (and what happens
if you don't)
- 8Tom Terwilliger (LANL, Los Alamos, US)
- Ligand libraries and Automated Ligand Fitting
in PHENIX
- 9Victor Lamzin (EMBL, Hamburg, Germany)
- Ligand building using ARP/wARP
- 10Paul Emsley (York University, UK)
- Ligand Search and Refinement using Coot
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