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Programme

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(*programme may be subject to change)

Monday 13 | Tuesday 14 | Wednesday 15 | Thursday 16 | Friday 17

Sunday 12 August 2007

16:00 - 18:00Registration (collect badges and delegate book): Bridgewater Hall Foyer
18:00Welcome Reception: Manchester Town Hall

Monday 13 August 2007

09:00 Opening Plenary: Shige Yokoyama (RIKEN, Japan): "The Changing Face of Structural Genomics/Proteomics"
10:00 Coffee/Tea: Exhibition Hall
10:30 - 12:30Parallel Sessions

Session 1Structural Genomics/Proteomics

Session organisersTom Terwilliger (Los Alamos, USA) and Harren Jhoti (Astex, Cambridge, UK)
Aled Edwards (SGC and University of Toronto, Canada): "Structural Chemistry Of Human Protein Families"
Andrzej Joachimiak (Argonne National Laboratory, USA): "Structural Genomics Programme"
Stephen Burley (SGX, San Diego, USA): "Fragment-based discovery of selective, orally bioavailable tyrosine kinase inhibitors for targeted treatment of human cancers"
Nathan Cowieson (University of Queensland, Australia): "Protein function via high throughput structure determination using SAXS, SRCD and cross-linking"

Session 2 SR Spectroscopy (Circular Dichroism, Infra-Red, Spectro-microscopy)

Session organisersMikio Kataoka (Japan) and Bonnie Wallace (Birkbeck, UK)
Robert Janes (Queen Mary, UK): "Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy: Applications In Structural Biology"
Paul Dumas (SOLEIL, France): "Sub cellular probing and imaging using synchrotron infrared microspectroscopy: a new diagnostic vision"
Laurence Barron (Glasgow, UK): "Raman Optical Activity: An Incisive Chiroptical Spectroscopy for Studies of Biomolecular Structure and Behaviour"
U-Ser Jeng (Hsinchu, Taiwan): "Solution X-Ray Scattering And Absorption On The Global and Local Structure changes Of Cytochrome-C in Unfolding"

12:30 Lunch: Exhibition Hall
14:00-16:00 Parallel Sessions

Session 3 Non-Crystalline Diffraction

Session organisersTom Irving (IIT, Chicago, USA) and Günter Grossmann (Daresbury, UK)
Shuji Akiyama (JST, Japan): "Real-time SAXS Observation of Assembling-Disassembling Complexes of Cyanobacterial Circadian Clock Proteins"
Fadel Samatey (Okinawa, Japan): "Bacterial flagella-fibre X-ray diffraction"
Keith Meek (Cardiff, UK): "The use of x-ray scattering to understand corneal structure and pathology"
Naoto Yagi (SPring-8 Center, Japan): "Microbeam X-Ray Diffraction Studies of Amyloid Spherulites"

Session 4 Combined SR techniques (Spectroscopy with PX)

Session organisersRichard Garratt (São Carlos, Brazil) and David Garner (Nottingham, UK)
Richard Strange (Daresbury, UK): "Combined X-Ray Methods For Structure-Function Studies Of Metalloproteins"
Peter Lay (Sydney, Australia): "Biomedical Applications of X-ray Absorption Spectroscopy"
Ilme Schlichting (Max-Planck, Heidelberg, Germany): "Combined use of Spectroscopy and crystallography for studying protein-ligand interactions in metalloproteins"
David Albesa-Jove (Imperial College, UK): "Recent advances in the structural characterization of Clostridium difficile toxins using macromolecular crystallography and SAXS techniques"

16:00 Coffee/Tea: Exhibition Hall
16:30Plenary: So Iwata (Imperial College/Diamond UK): "Are Membrane Proteins Still a Special Case?"
17:30Plenary: Malcolm Irving (King's College, UK): "Towards the Understanding of Muscle"
19:30Welcome dinner for all delegates (supported by Marresearch GmbH): The Midland Hotel

Tuesday 14 August 2007

09:00Plenary: Hartmut Michel (Max-Planck, Frankfurt, Germany): "Na+/N+-antiporter and cytochrome c oxidase, a comparison of two proton translocating enzymes"
10:00 Coffee/Tea: Exhibition Hall
10:30-12:30Parallel Sessions

Session 1 Developments in instrumentation: from photon delivery to detection

Session organisersSine Larsen (ESRF, France) and John Helliwell (Manchester, UK)
Andy Thompson (SOLEIL, France): "Instrumental developments on the PROXIMA 1 beamline for MX at SOLEIL"
Mike Soltis (SSRL, Stanford, USA): "New Paradigm for Protein Crystallography Experiments: Automated Remote Screening and Data Collection"
Clemens Schulze-Briese (SLS/PSI, Zurich, Switzerland): "Cool Data And Fast Detectors - The SLS MX Beamlines"
Kazuya Hasegawa (JASRI, Japan): "Protein Crystallography With Continuous Rotation Method Using Cmos Flat Panel Detector"

Session 2 Membrane proteins

Session organisersJohann Deisenhofer (Dallas, USA) and So Iwata (Imperial College/Diamond, UK)
Raimund Dutzler (Zurich, Switzerland): "The ion binding properties of ClC chloride channels and transporters"
Par Nordlund (Stockholm, Sweden): "Cobalt transporter"
Özkan Yildiz (Max-Planck-Institute of Biophysics, Frankfurt, Germany): "Structure of the monomeric outer-membrane porin OmpG in the open and closed conformation"
Shinnichiro Suzuki (Osaka University, Japan): "Electron transfer processes in a methylotrophic denitrifying bacterium: from methanol dehydrogenase to copper nitrite reductase"

12:30 Lunch: Exhibition Hall
12:45 - 13:45 imgCIF Workshop (further information & registration »): Barbirolli Room
14:00-16:00Parallel Sessions

Session 3 Metalloproteins

Session organisersSamar Hasnain (Daresbury, UK) and Chris Schofield (Oxford, UK)
Albrecht Messerschmidt (Martinsried, Germany): "Molybdenum-dependent pyrogallol-phloroglucinol transhydroxylase and tungsten-dependent acetylene hydratase"
James Murray (Imperial College, UK): "Photosystem II"
Yoshitsugu Shiro (RIKEN SPring-8 Center, Japan): "Inter-domain and Inter-molecular Signaling Pathwayin Two Component System: Histidine Kinase and Response Regulator"
Mike Hough (Daresbury, UK): "In situ optical and x-ray spectroscopy in structural biology: current and future perspectives of metalloproteins research"

Session 4 Imaging

Session organisersRob Lewis (Monash, Australia) and Keith Hodgson (Stanford, USA)
Stuart Hooper (Monash, Australia): "Imaging Lung Aeration at Birth"
Graham George (Saskatchewan, Canada): "Molecules, Cells and Organisms: Spectroscopic Imaging of Biological Tissues"
Carolyn Larabell (Berkeley, USA): "3D tomography of cells"
Ian Robinson (University College, UK): "Coherent and Solution Scattering investigation of the Nucleation of Protein Crystals"

16:00Coffee/Tea: Exhibition Hall
16:30 Plenary: Venki Ramakrishnan (MRC Cambridge, UK): "Ribosome and Protein-Nucleic acid complexes"
17:30-19:00 Posters: Nibbles/drinks
19:30 **Concert - Bridgewater Hall: "Samyo" (the National South Asian Youth Orchestra) & "Tarang" (the National South Asian Music Ensemble)

Wednesday 15 August 2007

09:00 Plenary: Dmitri Svergun (EMBL, Germany): "Structures of Proteins and their Complexes in Solution"
10:00 Coffee/Tea: Exhibition Hall
10:30-12:30Parallel Sessions

Session 1 Multi-protein complexes

Session organisersSoichi Wakatsuki (Photon Factory, KEK, Japan) and Louise Johnson (Diamond/Oxford, UK)
Roger Williams (LMB-MRC, Cambridge, UK): "ESCRT complexes"
Satoshi Murakami (Osaka, Japan): "Structural studies of multi-drug efflux transporter"
Hanna Yuan (Academia Sinica, Taiwan): "Structural and Functional Insight into Nucleases in Cell Defense"
Irmgard Sinning (Heidelberg, Germany): "The Single Recognition Particle"

Session 2SR Industrial Applications and structure based drug design

Session organisersAndrew Wang (Genomics Centre, Taiwan) and Richard Pauptit (AstraZeneca, UK)
David Brown (Pfizer, UK ): "The Role of Synchrotron Radiation in Drug Discovery"
Andreas Kuglstatter (Roche Pharmaceuticals, Palo Alto, USA): "p38 Kinase Inhibitors: From multiple leads to a drug candidate"
Harren Jhoti (Astex Therapeutics Ltd, Cambridge, UK): "Fragment-based drug discovery"
Charles Lesburg (Schering-Plough Research Institute, USA): "Engineered PXR Ligand Binding Domain for Inverse Structure-Based Drug Design"

12:30 Lunch: Exhibition Hall
14:00-16:00Parallel Sessions

Session 3 Computational Biology

Session organisersRandy Reed (Cambridge, UK) and Roger Fourme (SOLIEL, France)
Mike Sutcliffe (Manchester, UK): "Dynamically-coupled Enzyme Catalysis: Simulation Reveals Proton Tunnelling is Driven by a Short-range Sub-picosecond Promoting Motion"
Bernard Brooks (Bethesda, NIH, USA): "Multi-scale Methods for Macromolecular Systems in Computational Biophysics"
Gerald Kneller (CNRS - Orléans, France): "Computer simulations and experiments on biomolecular systems under pressure"
Mark Sansom (Oxford, UK): "Coarse Grained Simulations of Membrane Proteins: Protein/Lipid Interactions"

Session 4 New Biological Challenges

Session organisersAndres Liljas (Lund, Sweden) and Zihe Rao (Beijing, China)
Steve Oliver (Manchester, UK): "Yeast Genome: Molecules to Assemblies to System "
Yong Xiong (Yale, USA): "Atomic Structure Determination of Yeast Fatty Acid Synthase"
Zhi-Jie Liu (Beijing, China): "Structure and function analysis of human p100 TSN domain"
Robert Fischetti (Argonne National Laboratory, USA): "GM/CA-CAT's "mini-beam" apparatus provides 7 micron beam for macromolecular crystallography"

16:00Coffee/Tea: Exhibition Hall

Session 5 Recent Advancements

Session organisersSamar Hasnain (Daresbury, UK) and Louise Johnson (Diamond/Oxford, UK)
B C Wang (University of Georgia, USA): "Remaining Challenges In Long Wavelength Phasing: The SER-CAT Approach"
Eric Girard (SOLEIL, France): "Progress in instruments and methods towards fully-fledged high pressure macromolecular crystallography (HPMX). Recent structural results on nucleic acids and proteins"

17:30-19:30 Posters: with nibbles/drinks

Thursday 16 August 2007

09:00 Plenary: David Stuart (Oxford, UK): "Challenges of Structural Virology "
10:00 Coffee/Tea: Exhibition Hall
10:30 - 11:30 Parallel Sessions

Session 1 Hot topics

Session organisersTim Richmond (ETH, Switzerland) and Louise Johnson (Diamond/Oxford, UK)
Jim Naismith (St. Andrews, UK): "Wza, a new class of outer membrane protein"
Zihe Rao (Beijing, China): "SARS Virus Proteins"
Hanna-Kirsti Schrøder Leiros (Tromsoe, Norway): "Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H - reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability"
Hiro Tsuruta (SSRL/SLAC, Stanford University): "Spring-loaded inter-domain crosslinks regulate a global conformation switching in HK97 bacteriophage maturation"

Session 2 Radiation Damage: How to get the best from your sample?

Session organisersColin Nave (Daresbury, UK) and Janos Hajdu (Uppsala, Sweden)
Malcolm Howells (Berkeley, USA): "Principles Of Radiation Damage In Coherent X-Ray Diffraction Imaging"
Elspeth Garman (Oxford, UK): "An experimental determination of the radiation dose limit for cryo-cooled protein crystals."
Jim Penner-Hahn (Michigan, USA): "Radiation Damage of Redox-Sensitive Transition Metal Ions"
Vivian Stojanoff (Brookhaven National Laboratory, USA): "About The Use Of Ultra High X-Ray Energies In Macromolecular Crystallography"

12:30 Lunch: Exhibition Hall
14:00Plenary: Tom Blundell (Cambridge, UK): "From Structure to Drugs: Exploring Chemical and Biological Space "
15:00Coffee/Tea: Exhibition Hall
15:30Plenary: Keith Hodgson (Stanford, USA): "Structural Biology and Synchrotron Radiation: From First to Fourth Generation Accelerator Based Photon Sources"
16:15Plenary: Janos Hajdu (Uppsala, Sweden): "Flash Diffractive Imaging of Single Particles and Biomolecules"
17:00Special Plenary: Johann Deisenhofer (Dallas, USA): "Biology & SR - Current, Past & Future"
17:45 Concluding Ceremony
18:50-22:30GALA Dinner (supported by LJMU, Manchester Metropolitan University and the University of Liverpool ): Mere Golf and Country Club (transport will leave Manchester at 18:50)

Friday 17 August 2007 (**RAL/Diamond, Oxfordshire)

Travel to Diamond and Tour of Diamond Light Source: Special Travel Arrangements will be made for those who wish to travel to Diamond
12:30 Lunch
12:30 - 13:50 imgCIF Workshop (further information & registration »): Room 1.17 - Diamond House

Scientific Presentations

14:00Louise Johnson, Liz Duke, Nick Terrill (Diamond/Oxford, UK): "DIAMOND - Current Status and Latest Results"
14:30Michel van der Rest (SOLEIL, France): "SOLEIL, status and the life science programme"
15:00Peter Weightman (Liverpool, UK): "The Potential of the Fourth Generation Light Source for Research in Biology"
15:40Tour of the Facilities
17:00Departure

*programme may be subject to change
**extra charge for this function