Synchrotron Radiation Source, Daresbury Laboratory


Publications by Members of the Biology and Medicine College

Last updated 28th July  2008.
Please address comments / enquiries to: J.M.Nicholson@dl.ac.uk

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other years 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 |

2008

  1. Ambrosius P.L Snijders, Sayampong Pongdam, Christopher M. Wood, John P. Baldwin and Mark J. Dickman. (2008).
    Characterisation of post translational modifications of the linker histones H1 and H5 from chicken erythrocytes using mass spectrometry.
    Journal of Proteomics Research, in press.

  2. T.R. Rudd, M.A. Skidmore, S.E. Guimond, M. Guerrini, C. Cosentino, R. Edge, A. Brown, D.T. Clarke, G. Torri, J.E. Turnbull, R.J. Nichols, D.G. Fernig and E.A. Yates. (2008).
    Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques.
    Carbohydrate Research 343 (12), 2184-2193.

  3. A. J. Miles, R. W. Janes, A. Brown, D. T. Clarke, J. C. Sutherland, Y. Tao, B. A. Wallace and S. V. Hoffmann. (2008).
    Light flux density threshold at which protein denaturation is induced by synchrotron radiation circular dichroism beamlines.
    Journal of Synchrotron Radiation 15, 420-422.

  4. Grossmann, J.G., Callaghan, A.J., Marcaida, M.J., Luisi, B.F., Alcock, F.H. and Tokatlidis K. (2008).
    Complementing structural information of modular proteins with small angle neutron scattering and contrast variation.
    European Biophysics Journal with Biophysics Letters 37 (5), 603-611.

  5. Barbieri S., Murphy L.M., Sawers R.G., Eady R.R. and Hasnain S.S. (2008).
    Modulation of NO binding to cytochrome c ' by distal and proximal haem pocket residues.
    Journal of Biological Inorganic Chemistry 13 (4), 531-540.

  6. Anna L. Mallam, Shimobi C. Onuoha, J. Günter Grossmann and Sophie E. Jackson. (2008).
    Knotted Fusion Proteins Reveal Unexpected Possibilities in Protein Folding.
    Molecular Cell 30 (5), 642-648.

  7. Lata Govada, Liz Carpenter, Paula C.A. da Fonseca, John R. Helliwell, Pierre Rizkallah, Emily Flashman, Naomi E. Chayen, Charles Redwood and John M. Squire. (2008).
    Crystal Structure of the C1 domain of Cardiac Myosin Binding Protein-C: Implications for Hypertrophic Cardiomyopathy.
    Journal of Molecular Biology 378 (2), 387-397.

  8. James M. Nicholson, Colin D. Reynolds, Mark Dickman, Chris M. Wood and John P. Baldwin. (2008).
    Chromatin: The Biophysical Approach to Elucidating Structure and Function.
    Cell Cycle Control: New Research, in press.

  9. John A. Cowan and Colin Nave. (2008).
    The optimum conditions to collect X-ray data from very small samples.
    Journal of Synchrotron Radiation, in press.

  10. M. J. Ellis, S. G. Buffey, M. A. Hough and S. S. Hasnain. (2008).
    On-line optical and X-ray spectroscopies with crystallography: an integrated approach for determining metalloprotein structures in functionally well defined states.
    Journal of Synchrotron Radiation, in press.

  11. Attia Boudjemline, David T. Clarke, Neville J. Freeman, James M. Nicholson and Gareth R. Jones. (2008).
    Early stages of protein crystallization as revealed by emerging optical waveguide technology.
    Journal of Applied Crystallography 41 (3), 525-530.

  12. S.C. Onuoha, E.T. Coulstock, J.G. Grossmann and S.E. Jackson. (2008).
    Structural studies on the co-chaperone Hop and its complexes with Hsp90.
    Journal of Molecular Biology 379 (4), 732-744.

  13. Xiaohang Cao, Svetlana Antonyuk, Sai V. Seetharaman, Lisa J. Whitson, Alexander B. Taylor, Stephen P. Holloway, Richard W. Strange, Peter A. Doucette, Joan Selverstone Valentine, Ashutosh Tiwari, Lawrence J. Hayward, Shelby Padua, Jeffrey A. Cohlberg, S. Samar Hasnain and P. John Hart. (2008).
    Structures of the G85R variant of SOD1 in Familial ALS.
    Journal of Biological Chemistry 283, 16169-16177.

  14. Michael A. Hough, Svetlana V. Antonyuk, Richard W. Strange, Robert R. Eady and S. Samar Hasnain. (2008).
    Crystallography with on-line optical and X-ray absorption spectroscopy demonstrates an ordered mechanism in Cu-nitrite reductase.
    Journal of Molecular Biology 378 (2), 353-361.

  15. Alexandre R Gingras, Neil Bate, Benjamin T Goult, Larnele Hazelwood, Ilona Canestrelli, J Günter Grossmann, HongJun Liu, Nicholas SM Putz, Gordon CK Roberts, Niels ... (2008).
    The structure of the C-terminal actin-binding domain of talin.
    EMBO Journal 27, 458-469.

  16. Stephen E D Webb, Selene K Roberts, Sarah R Needham, Christopher J Tynan, Daniel J Rolfe, Martyn D Winn, David T Clarke, Roger Barraclough and Marisa Martin-Fernandez. (2008).
    Single molecule imaging and FLIM show different structures for high and low-affinity EGFRs in A431 cells.
    Biophysical Journal, 94, 803-819.

  17. Michael J. Walsh, Tariq G. Fellous, Azzedine Hammiche, Nigel J. Fullwood, Olaug Grude, Fariba Bahrami, James M. Nicholson, Hubert M. Pollock, Mairi Brittan, Pierre L. Martin-Hirsch, Malcolm R. Alison and Francis L. Martin. (2008).
    FTIR micro-spectroscopy identifies symmetric PO2-modifications as a marker of the putative stem cell region of human intestinal crypts.
    Stem Cells, 26 (1), 108-118.

  18. Alcock, F.H., Grossmann, J.G., Gentle, I.E., Likic, V.A., Lithgow, T. and Tokatlidis, K. (2008).
    Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space.
    Biochemical Journal 409, 377-387.

  19. S. J. Fisher, J. R. Helliwell, S. Khurshid, L. Govada, C. Redwood, J. M. Squire and N. E. Chayen. (2008).
    An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C.
    Acta Crystallographica D64, 658-664.

  20. Margit Pedersen, Leila Lo Leggio, J. Günter Grossmann, Sine Larsen and Karin Hammer. (2008).
    Identification of Quaternary Structure and functional domains of the CI repressor from Bacteriophage TP901-1.
    Journal of Molecular Biology 376 (4), 983-996.

  21. Andrew P. Dean, James M. Nicholson and David C. Sigee. (2008).
    Impact of phosphorus quota and growth phase on carbon allocation in Chlamydomonas reinhardtii: an FTIR microspectroscopy study.
    European Journal of Phycology, in press.

  22. David Sigee, Beatriz Estrada, James Nicholson and Andrew Dean. (2008).
    Molecular response of Anabaena flos-aquae to differing concentrations of phosphorus: A combined FTIR and X-ray microanalytical study.
    Phycological Research, in press.

  23. Salvado, N., Buti, S., Pantos, E., Bahrami, F., Labrador, A. and Pradell, T. (2008).
    The use of combined Synchrotron Radiation micro FT-IR and XRD for the characterization of Romanesque wall paintings.
    Applied Physics A: Materials Science and Processing 90, 67-73.

  24. Kohler, A., Sule-Suso, J., Sockalingum, GD., Tobin, M., Bahrami, F., Yang, Y., Pijanka, J., Dumas, P., Cotte, M., van Pittius, DG., Parkes, G. and Martens, H. (2008).
    Estimating and correcting Mie scattering in synchrotron-based microscopic Fourier transform infrared spectra by extended multiplicative signal correction.
    Applied Spectroscopy 62 (3), 259-266.

  25. Sylvie Beaufils, J. Gunter Grossmann, Anne Renault and Victor M. Bolanos-Garcia. (2008).
    Characterization of the Tetratricopeptide-Containing Domain of BUB1, BUBR1, and PP5 Proves That Domain Amphiphilicity over Amino Acid Sequence Specificity Governs Protein Adsorption and Interfacial Activity.
    Journal of Physical Chemistry B 112 (27), 7984-7991.

  26. Clarke, K., Edge, R., Johnson, V., Land, E. J., Navaratnam, S. & Truscott, T. G. (2008).
    Direct Observation of NH2 Reactions with Oxygen, Amino Acids, and Melanins.
    Journal of Physical Chemistry A 112 (6), 1234-1237.

  27. K. Clarke, R. Edge, E.J. Land, S. Navaratnam and T.G. Truscott. (2008).
    The sulphate radical is not involved in aqueous radiation oxidation processes.
    Radiation Physics and Chemistry 77 (1), 49-52.

  28. Roger H. Bisby, Rachel Brooke and Suppiah Navaratnam. (2008).
    Effect of antioxidant oxidation potential in the oxygen radical absorption capacity (ORAC) assay.
    Food Chemistry 3 (1), 1002-1007.

  29. MacDonald, M.A., Schaefers, F., Pohl, R., Poole, I.B., Gaupp, A. amd Quinn, F.M. (2008).
    A W : B4C multilayer phase retarder for broadband polarization analysis of soft x-ray radiation.
    Review of Scientific Instruments 79 (2), 025108.

  30. Aleema Westcott, Julie Fisher, Lindsay P. Harding, Pierre Rizkallah and Michaele J. Hardie. (2008).
    Self-Assembly of a 3-D Triply Interlocked Chiral [2]Catenane.
    Journal of the American Chemical Society 130 (10), 2950-2951.

  31. Colin Reynolds, James Nicholson and John Baldwin. (2008).
    Chromatin: cracking the chemical code.
    European Pharmaceutical Review Issue 4, 75-81.

  32. R. M. Keegan and M. D. Winn. (2008).
    MrBUMP: an automated pipeline for molecular replacement.
    Acta Crystallographica D64, 119-124.

2007

  1. Benjamin T. Goult, Jonathan D. Rapley, Caroline Dart, Ashraf Kitmitto, J. Günter Grossmann, Mark L. Leyland, and Lu-Yun Lian. (2007).
    Small-Angle X-ray Scattering and NMR Studies of the Conformation of the PDZ Region of SAP97 and Its Interactions with Kir2.1.
    Biochemistry 46 (49), 14117-14128.

  2. Yanling Lu, Stephen E. Harding, Terje E. Michaelsen, Emma Longman, Kenneth G. Davis, Álvaro Ortega, J. Günter Grossmann, Inger Sandlie, and Jose García de la Torre. (2007).
    Solution Conformation of Wild-Type and Mutant IgG3 and IgG4 Immunoglobulins Using Crystallohydrodynamics: Possible Implications for Complement Activation.
    Biophysical Journal, 93, 3733-3744.

  3. Ellis, M.J., Grossmann, J.G., Eady, R.R. and Hasnain, S.S. (2007).
    Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases.
    Journal of Biological Inorganic Chemistry, 12 (8), 1119-1127.

  4. Sigee, D.C., Bahrami, F., Estrada, B., Webster R.E. and Dean A. P. (2007).
    The influence of phosphorus availability on carbon allocation and P quota in Scenedesmus subspicatus: A synchrotron-based FTIR analysis.
    Phycologia, 46 (5), 583-592.

  5. Gabriel Rosenblum, Philippe E. Van den Steen, Sidney R. Cohen, J. Günter Grossmann, Jessica Frenkel, Rotem Sertchook, Nelle Slack, Richard W. Strange, Ghislain Opdenakker and Irit Sagi. (2007).
    Insights into the Structure and Domain Flexibility of Full-Length Pro-Matrix Metalloproteinase-9/Gelatinase B.
    Structure 15 (10), 1227-1236.

  6. Mojtaba Hadian, Brendan M Corcoran, Richard I Han, J Günter Grossmann and Jeremy P Bradshaw. (2007).
    Collagen Organisation in Canine Myxomatous Mitral Valve Disease, an X-ray Diffraction Study.
    Biophysical Journal 93, 2472-2476.

  7. Ali, S.A., Grossmann, J.G., Abbasi, A. and Voelter, W. (2007).
    Structural and conformational analysis of scorpion (Buthus sindicus) hemocyanin using low resolution techniques.
    Protein and Peptide Letters 14 (5), 481-488.

  8. Malkit Sami, Pierre J. Rizkallah, Steve Dunn, Peter Molloy, Ruth Moysey, Annelise Vuidepot, Emma Baston, Penio Todorov, Yi Li, Feng Gao, Jonathan M. Boulter and Bent K. Jakobsen. (2007).
    Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.
    Protein Engineering, Design & Selection 20, 397-403.

  9. Beresford, N., Patel, S., Armstrong, J., Szoor, B., Fordham-Skelton, A.P. and Tabernero, L. (2007).
    MptpB, a virulence factor from Mycobacterium tublerculosis, exhibits triple-specificity phosphatase activity.
    Biochemical Journal 406, 13-18.

  10. Timothy R. Rudd, Scott E. Guimond, Mark A. Skidmore, Laurence Duchesne, Marco Guerrini, Giangiacomo Torri, Cesare Cosentino, Alan Brown, David T. Clarke, Jeremy E. Turnbull, David G. Fernig and Edwin A. Yates. (2007).
    Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.
    Glycobiology 17, 983-993.

  11. John R. Helliwell and Naomi E. Chayen. (2007).
    Crystallography: A down-to-Earth approach.
    Nature 448, 658-659.

  12. White, G.F., Ottignon, L., Georgiou, T., Kleanthous, C., Moore, G.R., Thomson, A.J. and Oganesyan, V.S. (2007).
    Analysis of nitroxide spin label motion in a protein-protein complex using multiple frequency EPR spectroscopy.
    Journal of Magnetic Resonance 185 (2), 191-203.

  13. F. Yuan, T. Georgiou, T. Hillon, E. Gostick, D. A. Price, A. K. Sewell, R. Moysey, J. Gavarret, A. Vuidepot, M. Sami, J. I. Bell, G. F. Gao, P. J. Rizkallah and B. K. Jakobsen. (2007).
    Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.
    Acta Crystallographica F63, 758-760.

  14. Henning Tidow, Roberto Melero, Efstratios Mylonas, Stefan M. V. Freund, J. Guenter Grossmann, Jose Maria Carazo, Dmitri I. Svergun, Mikel Valle and Alan R. Fersht. (2007).
    Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex.
    PNAS 104, 12324-12329.

  15. Joe Lee, Ehsan Gazi, John Dwyer, Michael D. Brown, Noel W. Clarke, James M. Nicholson and Peter Gardner. (2007).
    Optical artefacts in transflection mode FTIR microspectroscopic images of single cells on a biological support: the effect of back scattering into collection optics.
    Analyst 132 (8), 750-755.

  16. H. U. Ahmed, M. P. Blakeley, M. Cianci, D. W. J. Cruickshank, J. A. Hubbard and J. R. Helliwell. (2007).
    The determination of protonation states in proteins.
    Acta Crystallographica D63, 906-922.

  17. Alex Grunau, Kalotina Geraki, J. Günter Grossmann and Aldo Gutierrez. (2007).
    Conformational Dynamics and the Energetics of Protein-Ligand Interactions: Role of Interdomain Loop in Human Cytochrome P450 Reductase.
    Biochemistry 46 (28), 8244-8255.

  18. Justyn W. Regini, J. Günter Grossmann, Peter Timmins, John J. Harding, Andrew J. Quantock, Stuart A. Hodson and Gerald F. Elliott. (2007).
    X-Ray- and Neutron-Scattering Studies of alpha-Crystallin and Evidence That the Target Protein Sits in the Fenestrations of the alpha-Crystallin Shell.
    Investigative Ophthalmology & Visual Science 48, 2695-2700.

  19. Shekunov, B.Y., Chattopadhyay, P., Tong, H.H.Y., Chow, A.H.L. and Grossmann, J.G. (2007).
    Structure and drug release in a crosslinked poly(ethylene oxide) hydrogel.
    Journal of Pharmaceutical Sciences 96 (5), 1320-1330.

  20. Richard W. Strange, Chin W. Yong, William Smith and S. Samar Hasnain. (2007).
    Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase.
    PNAS 104, 10040-10044.

  21. Paraskevopoulos, K., Hough, M.A., Sawers, R.G., Eady, R.R. and Hasnain, S.S. (2007).
    The structure of the Met144Leu mutant of copper nitrite reductase from Alcaligenes xylosoxidans provides the first glimpse of a protein–protein complex with azurin II.
    Journal of Biological Inorganic Chemistry 12, 789-796.

  22. J. G. Grossmann. (2007).
    Biological solution scattering: recent achievements and future challenges.
    Journal of Applied Crystallography 40 (Supplement), s217-s222.

  23. Keegan, R.M. and Winn, M.D. (2007).
    Automated search-model discovery and preparation for structure solution by molecular replacement.
    Acta Crystallographica D63, 447-457.

  24. Mccoy, A.J., Grosse-Kunstleve, R.W., Adams, P.D., Winn, M.D., Storoni, L.C. and Read, R.J. (2007).
    Phaser crystallographic software.
    Journal of Applied Crystallography 40, 658-674.

  25. Alessandro Arcovito, Maurizio Benfatto, Michele Cianci, S. Samar Hasnain, Karin Nienhaus, G. Ulrich Nienhaus, Carmelinda Savino, Richard W. Strange, Beatrice Vallone and Stefano Della Longa. (2007).
    X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy.
    PNAS 104, 6211-6216.

  26. Cole, D.K., Rizkallah, P.J., Boulter, J.M., Sami, M., Vuidepot, A.L., Glick, M., Gao, F., Bell, J.I., Jakobsen, B.K., Gao, G.F. (2007).
    Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.
    Proteins - Structure, Funcion & Bioinformatics 67, 65-74.

  27. Meier, C., Carter, L.G., Winter, G., Owens, R.J., Stuart, D.I. and Esnouf, R.M. (2007).
    Structure of 5-formyltetrahydrofolate cyclo-ligase from Bacillus anthracis (BA4489).
    Acta Crystallographica F63, 168-172.

  28. Entwistle, K.M., Kong, K., MacDonald, M.A., Navaranjan, N. and Eichhorn, S.J. (2007).
    The derivation of the microfibril angle in softwood using wide-angle synchrotron X-ray diffraction on structurally characterised specimens.
    Journal of Materials Science 42 (17), 7263-7274.

  29. Wang ZS, Wang HC, Zhu JT, Zhang Z, Wang FL, Xu Y, Zhang SM, Wu WJ, Chen LY, Michette AG, Pfauntsch SJ, Powell AK, Schafers F, Gaupp A, Cui MQ, Sun LJ and MacDonald MA. (2007).
    Complete polarization analysis of extreme ultraviolet radiation with a broadband phase retarder and analyzer.
    Applied Physics Letters 90 (8), Art. No. 081910.

  30. Wang ZS, Wang HC, Zhu JT, Zhang Z, Xu Y, Zhang SM, Wu WJ, Wang FL, Wang B, Liu L, Chen LY, Michette AG, Pfauntsch SJ, Powell AK, Schafers F, Gaupp A and MacDonald MA. (2007).
    Broadband Mo/Si multilayer transmission phase retarders for the extreme ultraviolet.
    Applied Physics Letters 90 (3), Art. No. 031901.

  31. Kasztovszky, Z., Visser, D., Kockelmann, W., Pantos, E., Brown, A., Blaauw, M., Hallebeek, P., Veerkamp, J., Krook, W. and Stuchfield, H.M. (2007).
    Combined prompt gamma activation and neutron diffraction analyses of historic metal objects and limestone samples.
    Nuovo Cimento della Societa Italiana di Fisica C - Geophysics and Space Physics 30 (1), 67-78.

  32. Farquharson, M.J., Geraki, K., Falkenberg, G., Leek, R. and Harris, A. (2007).
    The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system.
    Applied Radiation and Isotopes 65 (2), 183-188.

  33. Kong, K., Davies, R. J., MacDonald, M. A., Young, R. J., Wilding, M. A., Ibbett, R. N. and Eichhorn, S. J. (2007).
    Influence of Domain Orientation on the Mechanical Properties of Regenerated Cellulose Fibres.
    Biomacromolecules 8 (2), 624-630.

  34. Crisostomo, A.G., Moreno, R.B., Navaratnam, S., Wilkinson, J.A. and Bisby, R.H. (2007).
    Generation of superoxide and singlet oxygen from alpha-tocopherolquinone and analogues.
    Free Radical Research 41 (6), 730-737.

  35. Ruth Edge, Ali El-Agamey, Edward J. Land, Suppiah Navaratnam and T. George Truscott. (2007).
    Studies of carotenoid one-electron reduction radicals.
    Archives of Biochemistry and Biophysics 458 (2), 104-110.

  36. Pezzella, A., Crescenzi, O., Natangelo, A., Panzella, L., Napolitano, A., Navaratnam, S., Edge, R., Land, E. J., Barone, V. and d'Ischia, M. (2007).
    Chemical, Pulse Radiolysis and Density Functional Studies of a New, Labile 5,6-Indolequinone and Its Semiquinone.
    Journal of Organic Chemistry 72 (5), 1595-1603.

  37. Lionel Costenaro, J. Günter Grossmann, Christine Ebel and Anthony Maxwell. (2007).
    Modular Structure of the Full-Length DNA Gyrase B Subunit Revealed by Small-Angle X-Ray Scattering.
    Structure 15 (3), 329-339.

  38. Sara B.M. Whittaker, Graham R. Spence, J. Günter Grossmann, Sheena E. Radford and Geoffrey R. Moore. (2007).
    NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7.
    Journal of Molecular Biology 366 (3), 1001-1015.

  39. Crittell, S., Cheung, K.C., Hall, C., Ibison, M., Nolan, P., Page, R., Scraggs, D. and Wilkinson, S. (2007).
    Diffraction enhanced imaging of normal and arthritic mice feet.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 573 (1-2), 126-128.

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